Network target for screening synergistic drug combinations with application to traditional Chinese medicine
نویسندگان
چکیده
منابع مشابه
Application of Computer-Aided Drug Design to Traditional Chinese Medicine
Computer-aided drug design (CADD) is an interdisciplinary subject, playing a pivotal role during new drug research and development, especially the discovery and optimization of lead compounds. Traditional Chinese Medicine (TCM) modernization is the only way of TCM development and also an effective approach to the development of new drugs and the discovery of potential drug targets (PDTs). Disco...
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Traditional Chinese medicine (TCM), an age-old healthcare system derived from China, is a mainstream medicine in China and is also popular in many other parts of the world [1-3]. Due to historic reasons, the scientific base of TCM awaits consolidation but emerging evidence has be‐ gun to illustrate TCM as an area of important medical rediscoveries. For example, the 2011 Lask‐ er-DeBakey Clinica...
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Network pharmacology is becoming a cutting-edge research field in current drug discovery and drug development thanks to rapid progress in systems biology, network biology, and chemical biology. By integrating reductionist and systems approaches as well as computational and experimental methods, network pharmacology has great potential to act as the next generation mode of drug research. Network...
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Though many studies have been performed to elucidate molecular mechanism of traditional Chinese medicines (TCMs) by identifying protein-compound interactions, no systematic analysis at herb level was reported. TCMs are prescribed by herbs and all compounds from a certain herb should be considered as a whole, thus studies at herb level may provide comprehensive understanding of TCMs. Here, we pr...
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Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentions toward traditional Chinese medicine (TCM) for novel lead compounds. Despite the growing number of studies on TCM, there is no free 3D small molecular structure database of TCM available for virtual ...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2011
ISSN: 1752-0509
DOI: 10.1186/1752-0509-5-s1-s10